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METROGEL is contraindicated in patients using a background of hypersensitivity to metronidazole or to every other ingredient in the formulation.
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Sufferers with extreme hepatic disorder metabolize metronidazole slowly and gradually. This results in the accumulation of metronidazole and its metabolites in the plasma. Accordingly, for these kinds of people, metronidazole vaginal gel must be administered cautiously.
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Disulfiram-like reaction to alcohol has been noted with oral metronidazole, As a result the possibility of this kind of response occurring although on metronidazole vaginal gel therapy cannot be excluded.
Knowledge from perfectly-managed trials instantly evaluating metronidazole administered orally to metronidazole administered vaginally usually are not readily available.